What drugs to use after breast cancer surgery: latest treatment guidelines and hot spot analysis
Drug treatment after breast cancer surgery is a key part of patient recovery. In recent years, with the progress of medical research, drug selection options have been continuously optimized. This article combines hot topics and clinical data from the entire Internet in the past 10 days to sort out commonly used drugs and their mechanisms of action after breast cancer surgery.
1. The purpose of drug treatment after breast cancer surgery
Postoperative drug treatment mainly includes adjuvant chemotherapy, endocrine therapy, targeted therapy and immunotherapy, aiming to eliminate residual cancer cells, reduce the risk of recurrence and improve survival rate.
2. Classification of commonly used drugs after breast cancer surgery
| drug type | Representative medicine | Applicable people | Mechanism of action |
|---|---|---|---|
| chemotherapy drugs | Cyclophosphamide, docetaxel, epirubicin | High-risk or lymph node metastasis patients | Inhibit cancer cell division |
| endocrine therapy drugs | Tamoxifen, letrozole, anastrozole | Hormone receptor positive (ER+/PR+) patients | Block the effects of estrogen |
| Targeted therapy drugs | trastuzumab, pertuzumab | HER2-positive patients | Precisely attack the HER2 protein |
| immunotherapy drugs | Pembrolizumab (PD-1 inhibitor) | triple negative breast cancer patients | activate immune system |
3. Recent hot drugs and research progress
1.CDK4/6 inhibitors (such as abeciclib): Combined endocrine therapy can significantly extend progression-free survival and become a new option for hormone receptor-positive patients.
2.ADC drugs (such as Enhertu): Targeted therapy for patients with low HER2 expression, recent clinical trial data are impressive.
3.PARP inhibitors (such as olaparib): Used for patients with BRCA gene mutations to reduce the risk of recurrence.
4. Precautions for personalized medication
| patient type | preferred option | Treatment recommendations |
|---|---|---|
| hormone receptor positive | Endocrine therapy + CDK4/6 inhibitor | 5-10 years |
| HER2 positive | Targeted therapy + chemotherapy | 1 year (targeted drugs) |
| triple negative breast cancer | Chemotherapy±immunotherapy | Adjust according to installment |
5. Drug side effects management and rehabilitation suggestions
1.chemotherapy side effects: Bone marrow suppression and hair loss can be relieved by Shengbai needle and ice cap.
2.Endocrine therapy side effects: Decreased bone density requires calcium and vitamin D supplementation.
3.Targeted therapy side effects: Cardiotoxicity requires regular monitoring of cardiac function.
Conclusion
Postoperative medication for breast cancer needs to be formulated based on molecular classification, staging and individual differences. It is recommended that patients fully communicate with their attending doctors and choose the optimal treatment path based on the latest clinical research data.
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